DNA origami design software

The software package distributes a sequence editor with a set of tools for designing DNA origami structures:

Bitmap reader - import any shape as design object.
DNA origami fold - automatically finds a folding path through a shape.
3D generator - automatically generates a 3D atomic model of your design.
Oligotrack - accepts any sequence to be integrated in your design and outputs an oligo list for ordering.

Download:

The program currently runs on Mac and Linux
The program might be ported for Windows some time in the future, but for the moment here is a protocol on how to run SARSE in Virtualbox on Windows.
Click here to download SARSE - DNA origami v1.1
P.S. The earlier download file was dysfunctional.

Get started:

For usage please cite:

Andersen et al. DNA Origami Design of Dolphin-Shaped Structures with Flexible Tails. ACS nano (2008)

Contact:

Please send an email to This e-mail address is being protected from spambots. You need JavaScript enabled to view it marked "SARSE mailinglist" if you want to stay informed about updates of the SARSE - DNA origami package or marked "SARSE comment" if you have any questions or suggestions.

Related software:

DNA origami box with locks and keys

The DNA 'origami' method was extended into 3D to create an addressable DNA box on the nanometre scale that can be opened by externally supplied DNA 'keys'. The study appeared online in Nature, May 6, 2009:

More highlights

CDNA news

January 27, 2010

Professor Kurt Gothelf receives the EliteForsk award

Professor Kurt Vestager Gothelf, Department of Chemistry and iNANO, and director the of the CDNA center, recieves one of five EliteForsk (elite researcher) awards from the Minestry of Science, Technology and innovations.

Press release

EliteForsk link (in Danish)

December 18, 2009

"The Nano box" elected as the top Danish research result of 2009

The Danish engineering journal, Ingeniøren, has elected the DNA nano-box as the research breakthrough of the year 2009 for science and technology. In May 2009, researchers from CDNA, iNANO and University of Göttingen published an article in the journal Nature that described the design and production of the smallest box in the world.

News link at AU

July 2, 2009

Chemical coupling on DNA 4-Helix Bundles

The Gothelf group publishes a joint paper with Hao Yan at ASU in Bioconjugate Chemistry. The study describes the distance dependent interhelical coupling of organic rods incorporated in DNA 4-helix bundles.

Article link

Events

5-9/4-2010: MRS conference, San Francisco

27-30/4-2010: FNANO conference, Snowbird

14-17/6-2010: DNA16 conference, Hong Kong

Selected publications

Self-assembly of a nano-scale DNA box with a controllable lid (Nature, 2009)

A yoctoliter-scale DNA reactor for small molecule evolution (JACS, 2009)