Publication - Small molecule induced control in duplex and triplex DNA-directed chemical reactions

Small molecule induced control in duplex and triplex DNA-directed chemical reactions

Research Area:	Organic Nanochemistry	Year:	2010
Type of Publication:	Article
Authors:	Mikkel F Jacobsen Jens B Ravnsbaek Kurt Gothelf
Journal:	Organic & Biomolecular Chemistry	Volume:	8
Number:	1	Pages:	50-2
Month:	January

Abstract:
Triplex DNA binders can effectively control copper-catalysed alkyne-azide click reactions in DNA architecture, such that either duplex or triplex DNA directed reactions of terminally attached azides and alkynes occur, in the absence or presence of triplex DNA binder, respectively.
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CDNA highlights

Seminar by Ned Seeman

On Friday the 9th of October 2009 professor Ned Seeman visited CDNA to give an iNANO lecture on "DNA: Not Merely the Secret of Life". Ned Seeman pioneered the field of structural DNA nanotechnology by suggesting and demonstrating DNA as a building block for nanoscale science. His group at NYU continues to contribute major advances to the field, recently, nanomechanical devices, DNA walkers, and DNA crystals.

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CDNA news

May 2010: DNA nano-spider published in Nature

CDNA collaborator Hao Yan publishes the paper "Molecular robots guided by prescriptive landscapes". A molecular nanorobot dubbed a "spider" and labeled with green dyes traverses a substrate track built upon a DNA origami scaffold. It journeys towards its red-labeled goal by cleaving the visited substrates, thus exhibiting the characteristics of an autonomously moving, behavior-based robot at the molecular scale.

In the same issue of Nature DNA origami was used to create an assembly line for synthesizing gold nanoparticles.