Publication - Synthesis and electrochemical studies of an anthraquinone-conjugated nucleoside and derived oligonucleotides

Synthesis and electrochemical studies of an anthraquinone-conjugated nucleoside and derived oligonucleotides

Research Area:	Organic Nanochemistry	Year:	2009
Type of Publication:	Article	Keywords:	Anthraquinones,chemistry Dna Electrochemistry,methods Nucleosides Oligonucleotides,chemical synthesis
Authors:	M. F. Jacobsen E. E. Ferapontova K. V. Gothelf
Journal:	Org Biomol Chem	Volume:	7
Number:	5	Pages:	905-8


Note:
Mar 7
Abstract:
The synthesis of a 2'-deoxyuridine nucleoside linked to an anthraquinone moiety, and its incorporation into oligonucleotides are described, including a facile oxidative demethylation with phenyliodine(iii) bis(trifluoroacetate) to reveal the anthraquinone motif. Furthermore, some useful physical and electrochemical properties of the obtained oligonucleotide are also reported, which allow its principal use in electrochemical DNA assays.
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