Publications

Year: 2008

Chen, M. & Gothelf, K. V. (2008). Labeling of DNA via rearrangement of S-2-aminoethyl phosphorothioates to N-(2-mercaptoethyl)phosphoramidates. Org Biomol Chem, 6(5), 908-11. [More] [Digital version]

Weigelt, S., Busse, C., Bombis, C., Knudsen, M. M., Gothelf, K., Laegsgaard, E. et al. (2008). Surface synthesis of 2D branched polymer nanostructures. Angew Chem Int Ed Engl, 47(23), 4406-10. [More] [Digital version]

Andersen, E. S., Dong, M., Nielsen, M. M. & Jahn, K. (2008). DNA origami design of dolphin-shaped structures with flexible tails. ACS Nano, 2(6), 1213-8. [More] [Digital version]

Torarinsson, E., Yao, Z., Wiklund, E. D., Bramsen, J. B., Hansen, C., Kjems, J. et al. (2008). Comparative genomics beyond sequence-based alignments: RNA structures in the ENCODE regions. Genome Res, 18(2), 242-51. [More] [Digital version]

Rahbek, U. L., Howard, K. A., Oupicky, D., Manickam, D. S., Dong, M., Nielsen, A. F. et al. (2008). Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides. J Gene Med, 10(1), 81-93. [More] [Digital version]

Otero, R., Xu, W., Lukas, M., Kelly, R. E., Laegsgaard, E., Stensgaard, I. et al. (2008). Specificity of watson-crick base pairing on a solid surface studied at the atomic scale. Angew Chem Int Ed Engl, 47(50), 9673-6. [More] [Digital version]

Odadzic, D., Bramsen, J. B., Smicius, R., Bus, C., Kjems, J. & Engels, J. W. (2008). Synthesis of 2'-O-modified adenosine building blocks and application for RNA interference. Bioorg Med Chem, 16(1), 518-29. [More] [Digital version]

Nygaard, J. V., Andersen, M. O., Howard, K. A., Foss, M., Bunger, C., Kjems, J. et al. (2008). Investigation of particle-functionalized tissue engineering scaffolds using X-ray tomographic microscopy. Biotechnol Bioeng, 100(4), 820-9. [More] [Digital version]

Damgaard, C. K., Kahns, S., Lykke-Andersen, S., Nielsen, A. L., Jensen, T. H. & Kjems, J. (2008). A 5' splice site enhances the recruitment of basal transcription initiation factors in vivo. Mol Cell, 29(2), 271-8. [More] [Digital version]

Astakhova, I. V., Korshun, V. A., Jahn, K., Kjems, J. & Wengel, J. (2008). Perylene attached to 2'-amino-LNA: synthesis, incorporation into oligonucleotides, and remarkable fluorescence properties in vitro and in cell culture. Bioconjug Chem, 19(10), 1995-2007. [More] [Digital version]

Andersen, M. O., Howard, K. A., Paludan, S. R., Besenbacher, F. & Kjems, J. (2008). Delivery of siRNA from lyophilized polymeric surfaces. Biomaterials, 29(4), 506-12. [More] [Digital version]

Year: 2007

Mamdouh, W., Dong, M., Kelly, R. E., Kantorovich, L. N. & Besenbacher, F. (2007). Coexistence of homochiral and heterochiral adenine domains at the liquid,solid interface. J Phys Chem B, 111(42), 12048-52. [More] [Digital version]

Jacobsen, M. F., Andersen, C. S., Knudsen, M. M. & Gothelf, K. V. (2007). Synthesis of rigid homo- and heteroditopic nucleobase-terminated molecules incorporating adenine and,or thymine. Org Lett, 9(15), 2851-4. [More] [Digital version]

Clo, E., Snyder, J. W., Ogilby, P. R. & Gothelf, K. V. (2007). Control and selectivity of photosensitized singlet oxygen production: challenges in complex biological systems. Chembiochem, 8(5), 475-81. [More] [Digital version]

Busse, C., Weigelt, S., Petersen, L., Laegsgaard, E., Besenbacher, F., Linderoth, T. R. et al. (2007). Chiral ordering and conformational dynamics for a class of oligo-phenylene-ethynylenes on Au(111). J Phys Chem B, 111(21), 5850-60. [More] [Digital version]

Jacobsen, M. F., Clo, E., Mokhir, A. & Gothelf, K. V. (2007). Model systems for activation of nucleic acid encoded prodrugs. ChemMedChem, 2(6), 793-9. [More] [Digital version]

Weigelt, S., Busse, C., Nielsen, M., Gothelf, K. V., Laegsgaard, E., Besenbacher, F. et al. (2007). Influence of molecular geometry on the adsorption orientation for oligophenylene-ethynylenes on Au(111). J Phys Chem B, 111(39), 11342-5. [More] [Digital version]

Weigelt, S., Busse, C., Bombis, C., Knudsen, M. M., Gothelf, K. V., Strunskus, T. et al. (2007). Covalent interlinking of an aldehyde and an amine on a Au(111) surface in ultrahigh vacuum. Angew Chem Int Ed Engl, 46(48), 9227-30. [More] [Digital version]

Hansen, J. A., Sumbayev, V. V. & Gothelf, K. (2007). An electrochemical sensor based on the human estrogen receptor ligand binding domain. Nano Lett, 7(9), 2831-4. [More] [Digital version]

Jakobsen, M. R., Haasnoot, J., Wengel, J., Berkhout, B. & Kjems, J. (2007). Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites. Retrovirology, 4, 29. [More] [Digital version]

Howard, K. A., Dong, M., Oupicky, D., Bisht, H. S., Buss, C., Besenbacher, F. et al. (2007). Nanocarrier stimuli-activated gene delivery. Small, 3(1), 54-7. [More] [Digital version]

Liu, X., Howard, K. A., Dong, M., Andersen, M. O., Rahbek, U. L., Johnsen, M. G. et al. (2007). The influence of polymeric properties on chitosan,siRNA nanoparticle formulation and gene silencing. Biomaterials, 28(6), 1280-8. [More] [Digital version]

Howard, K. A. & Kjems, J. (2007). Polycation-based nanoparticle delivery for improved RNA interference therapeutics. Expert Opin Biol Ther, 7(12), 1811-22. [More] [Digital version]

Andersen, E. S., Lind-Thomsen, A., Knudsen, B., Kristensen, S. E., Havgaard, J. H., Torarinsson, E. et al. (2007). Semiautomated improvement of RNA alignments. Rna, 13(11), 1850-9. [More] [Digital version]

Bramsen, J. B., Laursen, M. B., Damgaard, C. K., Lena, S. W., Babu, B. R., Wengel, J. et al. (2007). Improved silencing properties using small internally segmented interfering RNAs. Nucleic Acids Res, 35(17), 5886-97. [More] [Digital version]

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CDNA highlights

Single-molecule chemical reactions on DNA origami

Researchers at the Danish National Research Foundation’s Centre for DNA Nanotechnology (CDNA) at iNANO demonstrate that it is possible to control chemical reactions on DNA nanostructures and generate images of reactions of individual molecules. The results were published on 28 February in Nature Nanotechnology. The article is available here

CDNA news

May 2010: DNA nano-spider published in Nature

CDNA collaborator Hao Yan publishes the paper "Molecular robots guided by prescriptive landscapes". A molecular nanorobot dubbed a "spider" and labeled with green dyes traverses a substrate track built upon a DNA origami scaffold. It journeys towards its red-labeled goal by cleaving the visited substrates, thus exhibiting the characteristics of an autonomously moving, behavior-based robot at the molecular scale.

In the same issue of Nature DNA origami was used to create an assembly line for synthesizing gold nanoparticles.