Publications

Year: 2010

Jacobsen, M. F., Ravnsbaek, J. B. & Gothelf, K. (2010). Small molecule induced control in duplex and triplex DNA-directed chemical reactions. Organic & Biomolecular Chemistry, 8(1), 50-2. [More] [Digital version]

Year: 2009

Andersen, E. S., Dong, M., Nielsen, M. M., Jahn, K., Subramani, R., Mamdouh, W. et al. (2009). Self-assembly of a nanoscale DNA box with a controllable lid. Nature, 459(7243), 73-6. [More] [Digital version]

Arian, D., Clo, E., Gothelf, K. & Mokhir, A. (2009). A Nucleic Acid Dependent Chemical Photocatalysis in Live Human Cells. Chemistry, . [More] [Digital version]

Andersen, C., Knudsen, M. M., Chhabra, R., Liu, Y., Yan, H. & Gothelf, K. (2009). Distance Dependent Interhelical Couplings of Organic Rods Incorporated in DNA 4-Helix Bundles. Bioconjugate Chem., 20(8), 1538–1546. [More] [Digital version]

Xu, W., Kelly, R. E., Gersen, H., Laegsgaard, E., Stensgaard, I., Kantorovich, L. N. et al. (2009). Prochiral Guanine Adsorption on Au(111): An Entropy-Stabilized Intermixed Guanine-Quartet Chiral Structure. Small, . [More] [Digital version]

Lukas, M., Kelly, R. E., Kantorovich, L. N., Otero, R., Xu, W., Laegsgaard, E. et al. (2009). Adenine monolayers on the Au(111) surface: structure identification by scanning tunneling microscopy experiment and ab initio calculations. J Chem Phys, 130(2), 024705. [More] [Digital version]

Mamdouh, W., Kelly, R. E., Dong, M., Jacobsen, M. F., Ferapontova, E. E., Kantorovich, L. N. et al. (2009). Self-Assembly of Artificial Nucleobase 1H-Benzimidazole-4,7-dione at the Liquid,Solid Interface. J Phys Chem B, 113(25), 8675-8681. [More] [Digital version]

Jacobsen, M. F., Ferapontova, E. E. & Gothelf, K. V. (2009). Synthesis and electrochemical studies of an anthraquinone-conjugated nucleoside and derived oligonucleotides. Org Biomol Chem, 7(5), 905-8. [More] [Digital version]

Hansen, M. H., Blakskjaer, P., Petersen, L. K., Hansen, T. H., Hojfeldt, J. W., Gothelf, K. et al. (2009). A yoctoliter-scale DNA reactor for small-molecule evolution. J Am Chem Soc, 131(3), 1322-7. [More] [Digital version]

Ferapontova, E. E. & Gothelf, K. V. (2009). Effect of serum on an RNA aptamer-based electrochemical sensor for theophylline. Langmuir, 25(8), 4279-83. [More] [Digital version]

Andersen, M. O., Howard, K. A. & Kjems, J. (2009). RNAi Using a Chitosan,siRNA Nanoparticle System: In Vitro and In Vivo Applications. Methods Mol Biol, 555, 77-86. [More] [Digital version]

Bramsen, J. B., Laursen, M. B., Nielsen, A. F., Hansen, T. B., Bus, C., Langkjaer, N. et al. (2009). A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity. Nucleic Acids Res, 37(9), 2867-81. [More] [Digital version]

Dyrskjot, L., Ostenfeld, M. S., Bramsen, J. B., Silahtaroglu, A. N., Lamy, P., Ramanathan, R. et al. (2009). Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro. Cancer Res, 69(11), 4851-60. [More] [Digital version]

Gao, S., Dagnaes-Hansen, F., Nielsen, E. J., Wengel, J., Besenbacher, F., Howard, K. A. et al. (2009). The Effect of Chemical Modification and Nanoparticle Formulation on Stability and Biodistribution of siRNA in Mice. Mol Ther, . [More] [Digital version]

Glud, S. Z., Bramsen, J. B., Dagnaes-Hansen, F., Wengel, J., Howard, K. A., Nyengaard, J. R. et al. (2009). Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration. Oligonucleotides, 19(2), 163-8. [More] [Digital version]

Year: 2008

Kelly, R. E., Lukas, M., Kantorovich, L. N., Otero, R., Xu, W., Mura, M. et al. (2008). Understanding the disorder of the DNA base cytosine on the Au(111) surface. J Chem Phys, 129(18), 184707. [More] [Digital version]

Kelly, R. E., Xu, W., Lukas, M., Otero, R., Mura, M., Lee, Y. J. et al. (2008). An investigation into the interactions between self-assembled adenine molecules and a Au(111) surface. Small, 4(9), 1494-500. [More] [Digital version]

Otero, R., Lukas, M., Kelly, R. E., Xu, W., Laegsgaard, E., Stensgaard, I. et al. (2008). Elementary structural motifs in a random network of cytosine adsorbed on a gold(111) surface. Science, 319(5861), 312-5. [More] [Digital version]

Otero, R., Xu, W., Lukas, M., Kelly, R. E., Laegsgaard, E., Stensgaard, I. et al. (2008). Specificity of watson-crick base pairing on a solid surface studied at the atomic scale. Angew Chem Int Ed Engl, 47(50), 9673-6. [More] [Digital version]

Xu, W., Dong, M., Gersen, H., Rauls, E., Vazquez-Campos, S., Crego-Calama, M. et al. (2008). Influence of alkyl side chains on hydrogen-bonded molecular surface nanostructures. Small, 4(10), 1620-3. [More] [Digital version]

Ferapontova, E. E., Olsen, E. M. & Gothelf, K. V. (2008). An RNA aptamer-based electrochemical biosensor for detection of theophylline in serum. J Am Chem Soc, 130(13), 4256-8. [More] [Digital version]

Sharma, J., Chhabra, R., Andersen, C. S., Gothelf, K. V., Yan, H. & Liu, Y. (2008). Toward reliable gold nanoparticle patterning on self-assembled DNA nanoscaffold. J Am Chem Soc, 130(25), 7820-1. [More] [Digital version]

Weigelt, S., Bombis, C., Busse, C., Knudsen, M. M., Gothelf, K. V., Laegsgaard, E. et al. (2008). Molecular self-assembly from building blocks synthesized on a surface in ultrahigh vacuum: kinetic control and topo-chemical reactions. ACS Nano, 2(4), 651-60. [More] [Digital version]

Andersen, C. S., Yan, H. & Gothelf, K. V. (2008). Bridging one helical turn in double-stranded DNA by templated dimerization of molecular rods. Angew Chem Int Ed Engl, 47(30), 5569-72. [More] [Digital version]

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CDNA highlights

March 2, 2010

Single-molecule chemical reactions on DNA origami

Researchers at the Danish National Research Foundation’s Centre for DNA Nanotechnology (CDNA) at iNANO demonstrate that it is possible to control chemical reactions on DNA nanostructures and generate images of reactions of individual molecules. The results were published on 28 February in Nature Nanotechnology. The article is available here

CDNA news

elena February 12, 2010

Electrochemical assay for attomole detection of DNA

The project was carried out in collaboration between CDNA and DTI. We combined a magnetic bead sandwich hybridization capture assay used for pre-concentration and bioseparation of target DNA, with a lipase-based amplification and electrochemical readout system. The signal amplification in the DNA assay is based on the catalytic activity of a lipase enzyme, and this “electrochemical blotting” concept is principally new. The use of this hydrolytic enzyme allowed for close to few-molecule detection of lipase-labeled DNAs at the electrode surface, due to accumulation of the catalysis product (ester bond cleavage and removal of the redox label from the zone of electrochemical reaction). The developed electrochemical lipase- and magnetic beads-based sandwich hybridization assay represents a fundamentally new electrochemical approach for sensitive DNA detection.

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