 February 12, 2010
Electrochemical assay for attomole detection of DNA The project was carried out in collaboration between CDNA and DTI. We combined a magnetic bead sandwich hybridization capture assay used for pre-concentration and bioseparation of target DNA, with a lipase-based amplification and electrochemical readout system. The signal amplification in the DNA assay is based on the catalytic activity of a lipase enzyme, and this “electrochemical blotting” concept is principally new. The use of this hydrolytic enzyme allowed for close to few-molecule detection of lipase-labeled DNAs at the electrode surface, due to accumulation of the catalysis product (ester bond cleavage and removal of the redox label from the zone of electrochemical reaction). The developed electrochemical lipase- and magnetic beads-based sandwich hybridization assay represents a fundamentally new electrochemical approach for sensitive DNA detection. ChemComm link |
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January 27, 2010 Professor Kurt Gothelf receives the EliteForsk award Professor Kurt Vestager Gothelf, Department of Chemistry and iNANO, and director the of the CDNA center, recieves one of five EliteForsk (elite researcher) awards from the Minestry of Science, Technology and innovations. Press release EliteForsk link (in Danish) |
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December 18, 2009 "The Nano box" elected as the top Danish research result of 2009 The Danish engineering journal, Ingeniøren, has elected the DNA nano-box as the research breakthrough of the year 2009 for science and technology. In May 2009, researchers from CDNA, iNANO and University of Göttingen published an article in the journal Nature that described the design and production of the smallest box in the world. News link at AU
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March 2, 2010