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Highlights
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 March 2, 2010
Single-molecule chemical reactions on DNA origami Researchers at the Danish National Research Foundation’s Centre for DNA Nanotechnology (CDNA) at iNANO demonstrate that it is possible to control chemical reactions on DNA nanostructures and generate images of reactions of individual molecules. The results were published on 28 February in Nature Nanotechnology. The article is available here |
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 Seminar by Ned Seeman
On Friday the 9th of October 2009 professor Ned Seeman visited CDNA to give an iNANO lecture on "DNA: Not Merely the Secret of Life". Ned Seeman pioneered the field of structural DNA nanotechnology by suggesting and demonstrating DNA as a building block for nanoscale science. His group at NYU continues to contribute major advances to the field, recently, nanomechanical devices, DNA walkers, and DNA crystals. |
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DNA origami box with locks and keysThe DNA 'origami' method was extended into 3D to create an addressable DNA box on the nanometre scale that can be opened by externally supplied DNA 'keys'. The study appeared online in Nature, May 6, 2009: |
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Construction of DNA dolphins with flexible tails
Dolphins from the Aarhus University seal were constructed in DNA. The novel DNA structures are characterized by Atomic Force Microscopy (AFM) and shown to have flexible tails. The study involves the development of new software to design DNA-nanostructures of any shape and is expected to advance the field of DNA nanotechnology. |
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CDNA highlights
March 2, 2010 Single-molecule chemical reactions on DNA origami Researchers at the Danish National Research Foundation’s Centre for DNA Nanotechnology (CDNA) at iNANO demonstrate that it is possible to control chemical reactions on DNA nanostructures and generate images of reactions of individual molecules. The results were published on 28 February in Nature Nanotechnology. The article is available here |
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CDNA news
 February 12, 2010
Electrochemical assay for attomole detection of DNA The project was carried out in collaboration between CDNA and DTI. We combined a magnetic bead sandwich hybridization capture assay used for pre-concentration and bioseparation of target DNA, with a lipase-based amplification and electrochemical readout system. The signal amplification in the DNA assay is based on the catalytic activity of a lipase enzyme, and this “electrochemical blotting” concept is principally new. The use of this hydrolytic enzyme allowed for close to few-molecule detection of lipase-labeled DNAs at the electrode surface, due to accumulation of the catalysis product (ester bond cleavage and removal of the redox label from the zone of electrochemical reaction). The developed electrochemical lipase- and magnetic beads-based sandwich hybridization assay represents a fundamentally new electrochemical approach for sensitive DNA detection. ChemComm link |
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January 27, 2010 Professor Kurt Gothelf receives the EliteForsk award Professor Kurt Vestager Gothelf, Department of Chemistry and iNANO, and director the of the CDNA center, recieves one of five EliteForsk (elite researcher) awards from the Minestry of Science, Technology and innovations. Press release EliteForsk link (in Danish) |
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December 18, 2009 "The Nano box" elected as the top Danish research result of 2009 The Danish engineering journal, Ingeniøren, has elected the DNA nano-box as the research breakthrough of the year 2009 for science and technology. In May 2009, researchers from CDNA, iNANO and University of Göttingen published an article in the journal Nature that described the design and production of the smallest box in the world. News link at AU
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